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People with specific variants of CYP2D6 enzymes may not produce adequate amounts of the active metabolite (desmetramadol) for effective pain control

This can severely reduce or even eliminate its biological activity, rendering your research sample useless

This irregularity often occurs during the initial months of treatment as the body adjusts to metabolic changes

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Older individuals may have different pharmacokinetics, meaning the peptide might be processed differently by the body