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It has been shown that pharmacological depletion of ATP inhibits RNA synthesis and leads to the apoptosis of CLL cells (6)

Furthermore, exercise can modulate the secretion of insulin-like growth factors, target distinct pathways like Akt and mTOR, and prompt apoptosis in cancer cells via diverse mechanisms, relevant in obese endometrial cancer patients where insulin resistance is a key pathogenic driver [93, 94]

Lipoic acid: Women with polycystic ovary syndrome who supplemented with lipoic acid showed an improvement in insulin sensitivity and a reduction in triglycerides, while improvements in menstrual regularity were also seen with a combination of lipoic acid and inositol