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Lastly, in the advanced stage, collagen becomes heavily cross-linked, and phenotypic changes of fibroblasts to myofibroblasts (MFBs) along with an atrophic epithelium are observed, which increases the risk for epithelial dysplasia and oral squamous cell carcinoma (OSCC) (Passi et al., 2017)

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Glycation-mediated inter-protein cross-linking is promoted by chaperone-client complexes of alpha-crystallin: Implications for lens aging and presbyopia

In the model group, mice exhibited transient weight loss as early as day 3 post-induction, accompanied by reduced food and water intake