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Recent evidence suggests that PEGylation is generally employed to increase molecular weight and protect the payloads and/or drug nanoparticles from proteolytic degradation (Harris and Chess, 2003), thereby expanding their applicability in Alzheimer's and enabling specific designs that (i) prolong circulation timeas PEG chain can mitigate a rapid uptake by the RES (Kong et al., 2020), (ii) play a role in physical stabilityby reducing particle agglomeration and/or protein corona effect (Guerrini et al., 2018) or providing a steric stability with targeted A aggregates (Singh et al., 2022), (iii) improve BBB penetration (Du et al., 2024), (iv) reduce immunogenicity and toxicity (Kochman et al., 2026), and (v) enable controlled drug release and improved pharmacokinetics (Turjeman et al., 2015)

doi: 10.1038/s41467-017-00952-3, 136

This suggests that oxidative stress can be exerted on gastric epithelial cells during H

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FIGURE 3 4.2.1 Improvement of the intestinal epithelial barrier function In fact, intestinal epithelial barrier dysfunction can be a major hallmark for the development of alcohol-associated liver diseases