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These require intubation and continuous EEG monitoring

Combination therapy also increases the risk of adverse effects, including nausea, flushing, headache, and blood-pressure changes

This not only serves as additional energetic resource, but also generates a number of biologically active molecules such as diacylglycerol, cholesterol, ceramide, sphingosine, PIP2, IP3 which are involved in the activation of a variety of signaling pathways associated with cancer progression, metastases and therapy resistance e.g

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