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Forty-seven subjects were divided into two major groups: healthy controls (n=11) and CP (n=36), according to probing depth (PD) and clinical attachment loss (CAL)

Although metformin is a common drug for managing DM, however, monotherapy treatment with any antidiabetic drug will necessitate dosage increment since type 2 DM (T2DM) deteriorates over time due to the increasing pancreatic -cell dysfunction and will eventually require a combination therapy approach with another antidiabetic medication

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