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Tet1 and Tet2 mainly regulates the level of 5-hydroxymethylcytosine (5hmC) in the promoter region of primordial germ cell (PGCs) genes or 5hmC inside PGCs gene, while Tet3-mediates paternal active DNA demethylation [7, 64, 65, 89, 94, 134, 161]

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Decoding the metabolic requirements of amino acids in different tissues and understanding how to target the metabolism and metabolic pathways of these amino acids is indispensable for improving the level of cancer treatment

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