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In ZDF hearts, the levels of glycolytic intermediatesincluding glucose, glucose-6-phosphate, fructose-1,6-bisphosphate, glycerone phosphate, and pyruvateand pentose phosphate pathway intermediatesincluding gluconate 6-phosphate, ribulose 5-phosphate, and erythrose 4-phosphate were significantly elevated, likely due to stagnation in both glycolysis and pentose phosphate pathway metabolism (Fig

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LPCAT3 inhibitors remodel the polyunsaturated phospholipid content of human cells and protect from ferroptosis