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In other experimental conditions, long-term exposure of the cells and animals to hyperglycemic conditions could develop insulin resistance, which leads to excess production of ROS (Afanasev, 2010

doi: 10.1158/1078-0432.CCR-05-0235
Environmental factors and host microbiomes shape host-pathogen dynamics

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The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naive T cells in situ
