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[DOI] [PubMed] [Google Scholar] 383.Vecht CJ, Haaxma-Reiche H, Noordijk EM, Padberg GW, Voormolen JH, et al

(ii) Developing orthotopic tumor-bearing animal models is particularly challenging due to the technical complexity of tumor transplantation surgery, the need for intensive post-operative care, the highly heterogeneous tumor microenvironment (TME) of pancreatic cancer, and the inherent variability in tumor growth and experimental timelines (Stribbling et al., 2024)

When internalized by NSCs, MNBs activate Piezo1 channels, leading to Ca 2+ influx, which activates the expression of BMP2 and increases the phosphorylation of SMAD, adjusting the expression of differentiation genes to prevent NSCs from expressing genes that promote cancer (Li J

When relief of pain from treatment with GnRH agonist supports continued therapy, the addition of add-back therapy reduces or eliminates GnRH agonist-induced bone mineral loss and provides symptomatic relief without reducing the efficacy of pain relief