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Thermal processes such as boiling or prolonged heating can result in up to 50% reduction in total phenolics, including luteolin, whereas controlled enzymatic or fermentative processing can enhance the aglycone content, thereby improving intestinal absorption and bioavailability ( 3.3 Pharmacokinetics and bioavailability A clear understanding of luteolins pharmacokinetic behavior is essential for translating its preclinical promise into therapeutic applications in reproductive disorders

This leads to the activation of various genes involved in programmed cell death, and promotes apoptosis.36 Transcriptional initiation is a crucial regulatory process that affects HIF-1 mRNA expression

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OGT is tyrosine-phosphorylated by the insulin receptor upon acute insulin stimulation and this phosphorylation increases the activity of the enzyme

[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Radeva L., Yordanov Y., Spassova I., Kovacheva D., Tzankova V., Yoncheva K