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In particular, folate is needed for closure of the neural tube early in pregnancy, and periconceptional supplementation with folic acid (that is, supplementation beginning one month before and continuing two months after conception) has been shown to dramatically reduce the incidence of neural tube defects (NTDs) (reviewed in 29 and 30)

Hyperoxaluria refers to high oxalate concentration in the urine and is seen in 1040% of people with calcium oxalate stones, though it can also be present in individuals without kidney stone disease (Curhan 2012)

The IFN- +874 A/A genotype compared to what other genotype can lead to an 8.9 times high risk of OPN, and thus this SNP is a potential susceptibility factor in developing peripheral neuropathy and that cytokine gene polymorphisms do not necessarily exert a major influence on neuropathy but instead probably are contributing factors in increased susceptibility to HIV-SN

A repeated-measures 1-way ANOVA test was used to assess differences of baseline plasma concentrations of BB and TMAO between multiple visits