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We showed that inherent anxiety at baseline and elevated expression of the mineralocorticoid receptors (MR) in the hippocampus predisposes to a stress-induced suppression of expression of metabotropic glutamate receptors-2 (mGlu2, a key inhibitor of spontaneous glutamate release) with development of depressive-like behavior via epigenetic mechanisms of histone acetylation [20]

Minich WB (2022) Selenium metabolism and biosynthesis of selenoproteins in the human body

In the peroxisomes, the longest chain FAs are shortened and transported to the mitochondria for -oxidation and total oxidation to CO 2 and H 2 O [85]

In conclusion, the results of this study not only further verified that FRP in AD treatment has the characteristics of multiple components, multiple targets, and multiple pathways through network pharmacology but also identified possible leading compounds with potential multi anti-AD activity

& Soria, J