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Clinical case studies of the hearts of human METH users have revealed severely reduced left ventricular (LV) ejection fraction, LV chamber dilatation, myocardial lesions, cardiac hypertrophy, fibrosis, and inflammation in relatively younger patients (50 years) with no other significant cardiac risk factors 6,9,10,11
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The effects of Idebenone on cardiac functions in FRDA patients were investigated in a phase III (IONIA) randomized, double-blind, controlled trial involving 70 paediatric patients
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