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doi: 10.1038/s41590-023-01428-x 140 HuangCWangYLiXRenLZhaoJHuYet al

Reduced oxidative capacity in macrophages results in systemic insulin resistance

When zinc binds to these sites, copper and iron are forced to undergo hydrolytic polymerization into unreactive structures, thereby prohibiting the catalysis of free radical formation and the initiation of lipid peroxidation [121,122,123]

Cell 92 , 759772 (1998)

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