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Alteration of renal carnitine metabolism by anticonvulsant treatment

Rare but Possible Side Effects Although rare, some people may experience stronger L-carnitine side effects, particularly if they have pre-existing medical conditions or take high doses for extended periods

& Inoue, M

This genetic variation is estimated to affect 1 in 350 males in the United States

It remains to be seen how practical and cost effective daily supplementation of carnitine with carbohydrate is Carnitine and endurance exercise The belief that carnitine is an ergogenic aid for endurance exercise is based on assumptions similar to the weight-loss assumptions: Carnitine concentration in muscle becomes too low to allow the transport of carnitine into the mitochondria to function at a high velocity Oral ingestion of carnitine increases the total carnitine concentration in muscle Any increase in muscle carnitine increases the oxidation rate of plasma FAs and intramuscular triacylglycerols during exercise Any increase in fatty acids will reduce muscle glycogen breakdown and postponing fatigue