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Sodium butyrate treatment disrupts this complex, restoring PRKN expression and mitophagy

Studies have shown that it significantly affects the recovery of connective tissue injuries such as ligament tears and muscle injuries

Best for: MTHFR mutations (C677T, A1298C) Supporting methylation directly Neurological symptoms (brain fog, neuropathy) Depression and mood disorders Elevated homocysteine Advantages: No conversion required immediately bioavailable Directly supports methylation cycle Crosses blood-brain barrier easily Lowers homocysteine effectively Potential downsides: Can cause overmethylation symptoms in sensitive individuals (anxiety, insomnia, irritability) May need to start with very low doses Not ideal for those with histamine issues or overmethylators Typical dosage: 500-5000mcg daily (start low) 2

PMID: 12818476 Sekhar RV, Patel SG, Guthikonda AP, et al