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Acneiform or skin changes have been reported with high-dose or frequent B12 administration, though the mechanism remains unclear

Dysfunctional hypothalamic function can be seen in ME/CFS patients in the form of up-regulation of hypothalamic 5-hydroxytryptamine (5-HT) receptors (441) and abnormal arginine/vasopressin responses to deprivation tests and water loading (440)

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