glutathione borrelia burgdorferi Dr. Joe Burrascano: A Masterclass

The Y1003 site, located in the juxtamembrane domain, is a negative regulatory site for c-MET signaling that acts by recruiting c-CBL (casitas B-lineage lymphoma) [Petrelli et al

In a cervical cancer cell line (HeLa), the compound reduced cell proliferation in a concentration- and time-dependent way and lowered expression of phospho-Akt and SIRT1, two proteins tied to tumor progression, while a non-cancer reference cell line was less affected

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When RNAi-treated animals were supplemented with GSH, mitochondrial fragmentation was not modulated, suggesting that PINK-1 and PDR-1 are necessary for GSH activity in attenuation of metabolite-induced fragmentation

Additionally, there is no specific carrier of GSH at the cell membrane level