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Neuropsychopharmacology, 27 (2), 279-281
Oxidized proteins can be rapidly degraded by the 20S proteasome so an increase in proteasome activity in cells would accelerate the removal of these damaged products (144, 308)
Metabolic adaptation also plays a role
Rare conditions like autoimmune lymphoproliferative syndrome (ALPS) have been linked to these changes, although overall evidence is limited 9
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