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confirmed using a 5/6 nephrectomy rat model that bacterial translocation induces systemic microinflammation (68)

Belkacemi Y, Grellier N, Ghith S, Debbi K, Coraggio G, Bounedjar A, et al

Among prediabetic participants, 87.7% reverted to normoglycemia with the combination, compared with 32.2% on placebo

To further identify the specific site that governs GHS-R mediated SNS-thermogenic regulation, we further generated a conditional knockout mouse line specifically targeting AgRP neurons 35

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