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Pro- and anti-inflammatory cytokine responses to a 164-km road cycle ride in a hot environment

60,61 A third redox-sensitive pathway groupincluding Wnt/-catenin, PI3K/AKT/mTOR, aryl hydrocarbon receptor (AhR), TGF-, calcium signaling, Janus kinase (JAK)/signal transducers and activators of transcription (STAT), hypoxia-inducible factor 1 (HIF1), NF-B, Nrf2, c-Jun N-terminal kinase (JNK), p38, and Ataxia-telangiectasia mutated (ATM)features components that shuttle between the cytoplasm and nucleus, allowing complex regulation of gene expression and cellular fate

But since your injection bypasses the gut, that particular interaction is not an issue for the injection itself

doi: 10.3390/brainsci11091133