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As she spoke with other parents of children with Down syndrome she noticed that some of their children had similar symptoms

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They are generally directed against specific components of the mitochondrial signal transduction pathway, and these agents might not be specific to lung disease and might also have off-target effects

doi: 10.1158/2326-6066.CIR-20-0384 90 WangWGreenMChoiJEGijonMKennedyPDJohnsonJKet al

In contrast, chronic excessive inflammation or tissue injury represents another potential consequence of trained immunity, contributing to the pathogenesis of diseases such as atherosclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease