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Description
Cell Developmental Biol
Craniofacial Res
J Bioremed Biodegr 6:291
For instance, in preclinical models, long-term ketamine exposure increases the expression of GABA receptor subunits in the prefrontal cortex while simultaneously reducing glutamate receptor subunits, impairing synaptic signaling and cognitive function ( Ketamine also downregulates brain-derived neurotrophic factor, particularly in the hippocampus, exacerbating deficits in synaptic plasticity and cognitive functions
doi: 10.1038/s41443-018-0054-2
