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Twice-daily dosing is used in some early-phase research protocols to maintain more consistent receptor activation during the initial neuroplasticity induction period, but this approach increases total daily exposure and may elevate the risk of off-target effects

Mice were placed at the end of the start arm and allowed to explore the start arm and the other for 5 min

In 2024, nearly 6 percent of middle and high school students used e-cigarettes, with 26.3 percent of users reporting daily use of e-cigarettes (205)Park-Lee E, et al

Most published evidence currently comes from laboratory and animal studies, with relatively few controlled human trials available
