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Iron preparations, zinc or indigestion remedies should not be taken within 2 hours of penicillamine (in order to prevent reduction in absorption of penicillamine)

The optic nerve lesions in both mouse models lacked some common features of PA but displayed some morphological and pathological features reminiscent of the NF1-associated human tumors (78)

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Experimental studies in animal models and study of the mutant proteins in cultured cells suggest that the defective proteins encoded by these genes cause cataracts by interfering with the normal function of lens fiber cells or by promoting their own aggregation and, perhaps, the aggregation of normal lens proteins

You can also see an increase in seizure frequency if you have any kind of seizure disorder