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Stromal fibrin further shapes the immune infiltration landscape by acting as both a physical barrier and biochemical niche that restricts CD8 + T cell and tumor-associated macrophage penetration from the tumor stroma into the tumor parenchyma (171)

10.1677/joe.0.1130365 3

Melatonin can further activate MT1 and MT2 receptors, upregulating antioxidative defensive systems by increasing the expression or activity of antioxidant enzymes such as superoxide dismutase and glutathione peroxidase [3]

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C.YangJ.et al
