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Ashok AH, Mizuno Y, Volkow ND, Howes OD

In bioengineered tissues, mimetics of native oxygen gradients remain under investigation

These effects were associated with increased Nrf2 activation and the upregulation of downstream antioxidant enzymes like HO-1 and NQO1

doi: 10.1002/hep.30160

Newgard et al., 2009
