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Naud C, Marti B, Fernandez C et al
Although BMD is variable in T1DM and T2DM, prolonged hyperglycemia promotes changes in bone metabolism and destroys bone micro-architecture through multiple mechanisms, such as production of AGEs, inflammation, calcium and phosphorus metabolism disorders, and oxidative stress (112)
Steroids 103 , 89104 (2015)
Third, inflammation-induced oxidative stress amplification
The different mechanisms explain why some patients benefit from combination therapy
