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Model fitting, refinement, and validation For the CBS FL basal state structures, initially, three CBS 516525 structures (PDB: 4COO) were fitted using Molrep 55 and the missing loop 513527 was manually built in Coot 56

In the experiment conducted at least 24 h later, the mice received an IP administration of either vehicle, atenolol, or metoprolol in a between-subjects design

Regular use and maintenance are required to sustain any lightening effects, and results can vary among individuals

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The authors evaluated oxidative stress on the basis of GST activity and nitric oxide and MDA concentration in plasma
