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Exceeding this daily limit increases the risk of liver toxicity, which can lead to acute liver failure and, in severe cases, the need for a liver transplant

No additional individuals or organizations contributed to this work beyond the listed authors

However, further prospective cohort studies with clinical endpoints in healthy subjects, and results from on-going randomized, placebo-controlled interventional trials are awaited to truly define the efficiency of homocysteine-lowering therapy in the prevention and correction of vascular disorders among patients with occlusive coronary artery, cerebrovascular and peripheral vascular diseases, and thrombosis related to hyperhomocysteinemia

2000 Sep;71(3):239-45

Blakley, B.R., & Bell, R.J
