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NAD, Sirtuins (SIRT1) and Obesity NAD and nicotinamide play key roles in many cellular functions [111, 19]

Cells were either cultured in presence of 2-DG or not

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By inhibiting NNMT, 5-Amino-1MQ prevents the age-associated drain on NAD+ pools, effectively maintaining cellular NAD+ availability at more youthful levels
