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In addition, R848-loaded mannosan decarboxylated polylactic acid nanoparticles (Man-pD-PLGA-NP@R848) can target TAMs in a mannose receptor-mediated manner and further reprogram TAMs to an anti-tumor phenotype thereby inhibiting tumor progression by reprogramming immunosuppressive TME from cold tumors to hot tumors (42)

Maintaining 10 or more rotation sites for frequent dosing allows adequate tissue recovery between injections

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Archived from the original on January 25, 2012

These changes were characterized by either an increase in muscle size and density or a reduction in fat content