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(1974) there are three major molecular forms separable by isoelectric focusing, having isoelectric points of 5.2, 5.3, and 5.5

doi:10.1172/JCI114287

Partial punch biopsy may suffice only for low-risk cases, but close follow-up is then required

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1991 (landmark Italian trial): A double-blind, placebo-controlled trial involving 130 patients with Alzheimer's disease demonstrated that one year of ALCAR treatment resulted in a slower rate of deterioration compared to placebo across 13 of 14 outcome measures, including significant improvements in the Blessed Dementia Scale, logical intelligence, verbal critical abilities, long-term verbal memory, and selective attention [5][17]