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Findings from these early brain imaging studies have recently been corroborated by the employment of more stringent and sensitive parameters, thus confirming the interpretation that serotonergic neurotransmission is subject to long-lasting and subtle alterations following MDMA abuse in humans (Kish et al., 2010a,b)

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Using nuclear magnetic resonance (NMR) spectroscopy, Smeland and colleagues also demonstrated increased levels of norepinephrine and serotonin in the cortex of healthy mice, after 25 days of treatment with acetylcarnitine at a daily dose of approximately 0.5 g/kg body weight [117]

Castro-Marrero J, Saez-Francas N, Segundo MJ, et al