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In addition to generating nuclear DNA adducts, platinum drugs increase mtROS via formation of mitochondrial DNA adducts [104], [105], [106], the extent of which correlates with cytotoxicity [24], [107]
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Our results indicate that genetic impairment of both the thioredoxin and glutathione-dependent pathways can hinder the consumption of NADPH upon pro-oxidative challenges in the yeast cytosol, but the impact of blocking the glutathione pathway is more pronounced
TSI Antibodies Reference Ranges The reference ranges for thyroid-stimulating hormone antibodies varies
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