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Description
Continuous administration without washout can lead to adaptive downregulationwhere receptors become less responsive to MOTS-c signaling or NNMT inhibition becomes less effective due to compensatory upregulation
Data availability Source data are provided with this paper
doi: 10.1038/sc.2015.206

For clients who have both fat-loss goals and musculoskeletal issues (e.g., the users interest in mobility/gut recovery, serum therapies, peptides) this could be a conceivable fit though evidence is not robust yet

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