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This framework highlights that while neural crest markers are associated with dedifferentiated melanomas (Landsberg et al., 2012), there is a subset of even further dedifferentiated melanomas lacking neural crest markers (e.g., NGFR-), and displaying differential HMG box marker expression (SOX10-, SOX9+) (Figures 1E and 1F)

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What we do know is that maintaining levels above 400 pg/mL ensures optimal red blood cell production critical for oxygen delivery during intense training