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The TgAPParc mouse model, which carries the E693G mutation (APP695) under the control of the murine Thy1.2 promoter, exhibited 3- to 7-fold higher mutant human APP expression compared to endogenous mouse APP

[LINK NOT AVAILABLE], which can yield both underlying resistance to therapy as well as distinct vulnerabilities

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g- and ng-regimens mean a common beneficial effect [27]
