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Others are gain-of-function mutations in cytosolic and mitochondrial isocitrate dehydrogenase (IDH) isoforms 1 and 2 with the production of 2-hydroxyglutarate (2-HG)

Generally well tolerated at recommended doses

For skin whitening, we recommend a personalized consultation where well evaluate your skin and recommend suitable therapy with an adequate number of sessions

Patch Test First: If you have sensitive skin, test the lotion on a small area before full application to ensure no adverse reactions

The rate of IV injection should generally not exceed 150 mg/minute (1.5 mL of a 10% concentration or its equivalent), except in severe eclampsia with seizures (see below)