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In vivo , ITGB2-AS1 inhibition reduces cisplatin resistance, indicating that ITGB2-AS1 promotes cisplatin resistance in NSCLC by blocking p53-mediated ferroptosis via the FOSL2/NAMPT pathway ( SDCBP2-AS1 expression is increased in lung cancer cells, and its downregulation enhances ferroptosis

Multiple observational studies conducted across different populations have shown associations between frequent and long-term use of acetaminophen in pregnancy and some negative effects on a childs neurodevelopment

On the other hand, the cell-specific ZnT8-null mice displayed impaired morphology of -cell granules and insulin processing as well as reduced first phase insulin secretion 93

Early nutritional support may provide the greatest benefits by limiting secondary injury processes