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1 2 "Williams Receives "Decade of Behavior" Award"

The in-vitro findings revealed that circPVT1 is ceRNA for miR-3666, a miRNA found in lower levels in HCC tissues

Lastly, in contrast to GLO1, we found GLO2 protein levels to be downregulated and its precursor sLG to be upregulated by hypoxia in lung cancer cells, suggesting that hypoxic cells need to detoxify MG either by alternative routes 47,70 or perhaps they rather accumulate the nontoxic intermediate sLG than producing higher levels of D-lactate, which would further increase acidification next to the already upregulated anaerobic L-lactate production from pyruvate

In astrocytes, Nrf2 activators promote the translocation of Nrf2 from the cytoplasm to the nucleus, where it binds to the antioxidant response element (ARE), upregulating the expression of a series of antioxidant and detoxifying enzymes such as heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1)

S.PogginM.et al (2008)
