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The SPRINT trial, composed of 9,361 patients randomized into intensive and standard blood pressure control with the primary outcome being a composite of severe cardiovascular events

Regardless of treatment adherence, the data gathered from all participants of the study indicated a similar decrease in weight from baseline levels

8 This was the first trial in patients with a first acute demyelinating event (now, clinically isolated syndrome) to show efficacy in delaying time-to-clinically definite MS and was recognized as a significant medical advance as it introduced the concept of early treatment and led to revisions in diagnostic criteria for MS

Common side effects are mild and temporary, including injection site soreness, headaches, lightheadedness, mild nausea, and fatigue