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Importantly, we found that the increase in FMD after 4 weeks of CIT+GSH was 0.91 SD greater vs

In cachexia, systemic inflammation elevates hepatic hepcidin, reducing intestinal iron absorption and sequestering iron in macrophages, thereby limiting iron availability for erythropoiesis and mitochondrial oxidative metabolism in skeletal muscle ( 7.2 Treatment of ID Dietary iron is obtained from heme sourcessuch as red meat, poultry, and fishand non-heme sourcessuch as legumes, leafy greens, nuts, and fortified cereals ( Given the negative impact of ID on tumor progression and patient prognosis, iron supplementation therapy is gaining attention in the clinic

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Sci Transl Med 11(478):eaau5266 Rouschop KM, van den Beucken T, Dubois L, Niessen H, Bussink J, Savelkouls K et al (2010) The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5