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Efficacy and safety of LY3298176 (Tirzepatide), a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes (Phase 2 trial)

Retatrutide is an investigational triple receptor agonist targeting GLP-1, GIP, and glucagon receptors not yet licensed by the MHRA or EMA for use in the UK

PMID 32571178

AA is an n-6 PUFA that serves as a precursor of pro-inflammatory eicosanoids, while DHA, an n-3 PUFA is involved in anti-inflammatory responses [177]

Previously unreported effects of RSL3, such as degradation of mTOR signaling pathway protein, p70S6K, and reduction of p-NPM1 levels were identified in the present study and warrant further investigation