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Peer review Peer review information Nature Communications thanks Agnieszka Piekielko-Witkowska and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Methods Ethics approval and consent to participate The animal care and treatment protocols used in this paper follow the Guiding Principles for Animal Care and Use (China) and have been approved by the Ethics Committee of Shandong Provincial Hospital (approval no.: 2022-130)

This protection ensures ATP production continues efficiently, which directly supports energy levels, muscle recovery, and overall performance

Membranes were blocked with 5% (w/v) milk powder in PBS for 1 h and incubated for 16 h at 4 C with one of the following primary antibodies: rabbit anti-SLC31A1/CTR1 (Abcam, Cambridge, UK), mouse anti-GAPDH (Santa Cruz Biotechnology, Dallas, TX, USA), mouse anti-XPF (Thermo Fisher, Waltham, MA, USA), mouse anti-ERCC1 (Santa Cruz Biotechnology), mouse anti-Tubulin (Abcam), rabbit anti-NRF2 (Abcam)

Searle et al., 2022)