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miR144 was the first identified miRNA for the decreasing of Nrf2 protein level via targeting two distinct sites in the Nrf2 untranslated region.170 Similarly, miR28 targets the 3'UTR of Nrf2 mRNA and decreases Nrf2 protein expression.171 Identified proteins that involved in the regulation of Nrf2 signaling pathway, such as protein kinases, provide more opportunities to modulate Nrf2 pathway

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