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Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis

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In addition, increased ganglioside GM3(GM3) in the renal cortex during the early stages of diabetes alters pro-survival receptor-related Automatic Kernel Tunables (Akt) and Protein kinase B signaling to exacerbate DKD (6568)