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Chance Richards, Box Elder, Sr., 15801.0
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An in-depth mechanistic study has shown that activation of the BDNF signaling pathway significantly increases protein levels of neurexin- and neuroligin 1 and synaptic plasticity in the hippocampus, possibly involving TrkB/PI3k/AKT/mTOR in this process [54]
Here is a framework based on the clinical evidence
10.1093/brain/aws360 226 YangW.Tiffany-CastiglioniE
