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This inverse relationship between body size and lifespan is unique to domestic dogs and is thought to result from accelerated growth rates and higher metabolic demands in large breeds, which may increase oxidative damage and cellular damage [64]

In a pilot study in Thailand, Sangsuwan and Asawanonda tested the influence of daily intake of oral collagen (5 g) for 4 weeks on skin elasticity, especially in sun-exposed areas, in a randomized, double-blind, placebo-controlled trial (in a total of 36 women, aged 4060 years, where one-half of the participants were in the treatment group [ n = 18] or the placebo group [ n = 18]) [39]

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GSH plays an important role in the cardiovascular system because it is an important antioxidant that restores intracellular redox equilibrium and prevents the inactivation of nitric oxide produced by the endothelium, leading to aberrant vasomotor reactivity in individuals with coronary spastic angina [75,76]

Prdxs proceed the same catalytic cycle, where the active site cysteine (peroxidatic cysteine, Cys P ) reduces peroxides and forms Cys P -sulfenic acid (RSOH), releasing water or the corresponding alcohol